Group sequential designs for clinical trials.
نویسندگان
چکیده
منابع مشابه
Group sequential designs for developing and testing biomarker-guided personalized therapies in comparative effectiveness research.
Biomarker-guided personalized therapies offer great promise to improve drug development and improve patient care, but also pose difficult challenges in designing clinical trials for the development and validation of these therapies. We first give a review of the existing approaches, briefly for clinical trials in new drug development and in more detail for comparative effectiveness trials invol...
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Adaptive designs have been proposed for clinical trials in which the nuisance parameters or alternative of interest are unknown or likely to be misspecified before the trial. Although most previous works on adaptive designs and mid-course sample size re-estimation have focused on two-stage or group-sequential designs in the normal case, we consider here a new approach that involves at most thre...
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ورودعنوان ژورنال:
- Biometrics
دوره 29 3 شماره
صفحات -
تاریخ انتشار 1973